The Nagalase Test
Nagalase is an enzyme that suppresses your immune system. (1) (2) (4) (5)
Nagalase is short for "alpha-N-acetylgalactosaminidase"
What do Chronic Fatigue Syndrome, Cancer, AIDs, Autism & Lupus have in common?
- Viruses (like Influenza, HIV, Epstein-Barr and herpes zoster) secrete Nagalase. (1) (2) (9)
- Cancer cells secrete Nagalase. (3) (4) (5)
- Nagalase accumulates in the serum of cancer patients and its activity correlates with tumor burden, aggressiveness and clinical disease progression. (11)
- Of 400 Autistic Children tested, 80% of them had high Nagalase. (6)
- Chronic Fatigue is an immune system dysfunction, often with evidence of viral persistence. (7)
- 33 x Systemic Lupus Erythematosus patients were found to have high Nagalase. (8)
- Nagalase as a non-invasive way of evaluation of melanoma severity. (10)
For a list of NZ Doctors who treat high Nagalase with GcMAF go to our Doctors Page.
Book Your Nagalase Test.We organise the Nagalase Test in New Zealand.
The cost is $380 in Auckland. (Outside of Auckland will attract a secondary Lab charge, payable direct to them)
Blood is received by "Labtests", at 37- 41 Carbine Road, Mt Wellington, Auckland 1060.
Samples are frozen at -70°C and batched before transport to the Netherlands for testing.
For the South Island, contact Christine.Leaver@cdhb.health.nz at the Christchurch Public Hospital. Chris can organise the taking of the sample and the delivery of it to Labtests in Auckland.
The next batch opens on Monday the 3rd of November 2014, and closes on Friday the 5th of December 2014 at 4pm. Blood must be received between these dates to be included in this batch.
The following batch opens on Monday the 2nd of February 2015, and closes on Friday the 6th of March 2015 at 4pm. Blood must be received between these dates to be included in this batch.
Note: All patient information is held in strict confidence.
= Input Required
After booking your test, you will be taken to instructions for paying for the Nagalase Test.
On that page you will also need to download the forms necessary for ...
37- 41 Carbine Road
Mt Wellington, Auckland 1060.
Ph: 09 574 7399
You (or your frozen lab prepared sample) can turn up anytime (that a batch is open) with the forms between the hours of 8AM to 4PM, Monday to Friday.
Currently we are aware that an intake of Niclosamide or Hydroxocobalamin, within five days of the blood draw interferes with the Nagalase Test results. Also, always draw blood for the Nagalase test, as far away as possible from your last GcMAF injection.
Results: It is normal for nagalase test results to be received around 6 weeks after the batch closes.
(1) Yamamoto N, Urade M.
Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the hemagglutinin of influenza virus.
Microbes Infect. 2005 Apr;7(4):674-81. Epub 2005 Mar 22. Link to Abstract
(2) Yamamoto N.
Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the envelope glycoprotein gp160 of human immunodeficiency virus Type 1.
AIDS Res Hum Retroviruses. 2006 Mar;22(3):262-71. Link to Abstract
(3) Korbelik M, Naraparaju VR, Yamamoto N.
The value of serum alpha-N-acetylgalactosaminidase measurement for the assessment of tumour response to radio- and photodynamic therapy.
Br J Cancer. 1998 Mar;77(6):1009-14. Link to Abstract
(4) Yamamoto N, Naraparaju VR, Urade M.
Prognostic utility of serum alpha-N-acetylgalactosaminidase and immunosuppression resulted from deglycosylation of serum Gc protein in oral cancer patients.
Cancer Res. 1997 Jan 15;57(2):295-9. Link to Abstract
(5) Yamamoto N, Naraparaju VR, Asbell SO.
Deglycosylation of serum vitamin D3-binding protein leads to immunosuppression in cancer patients.
Cancer Res. 1996 Jun 15;56(12):2827-31. Link to Abstract
(6) Dr Jeff Bradstreet, MD, MD(H), FAAFP.
An Update on Viral Issue in Autism.
http://drbradstreet.org/category/autism/ (Retrieved 22/10/2011) Link to Webpage
(7) Bansal AS, Bradley AS, Bishop KN, Kiani-Alikhan S, Ford B.
Chronic fatigue syndrome, the immune system and viral infection.
Brain Behav Immun. 2011 Jul 2. [Epub ahead of print] Link to Abstract
(8) Yamamoto N, Naraparaju VR, Moore M, Brent LH.
Deglycosylation of serum vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus.
Clin Immunol Immunopathol. 1997 Mar;82(3):290-8. Link to Abstract
(9) Yamamoto, Nobuto (Philadelphia, PA)
Preparation of potent macrophage activating factors derived from cloned vitamin D binding protein and its domain and their therapeutic usage for cancer, HIV-infection and osteopetrosis.
United States Patent 6410269. Link to Patent
(10) Greco M, Mitri MD, Chiriaco F, Leo G, Brienza E, Maffia M.
Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: association to tumor derived alpha-N-acetylgalactosaminidase activity.
Cancer Lett. 2009 Oct 8;283(2):222-9. doi: 10.1016/j.canlet.2009.04.001. Epub 2009 Apr 25. Link to Abstract
(11) Lynda Thyer, Emma Ward, Rodney Smith, Jacopo JV Branca, Gabriele Morucci, Massimo Gulisano, David Noakes, Robert Eslinger, Stefania Pacini.
GC protein-derived macrophage-activating factor decreases a-N-acetylgalactosaminidase levels in advanced cancer patients.
OncoImmunology. 2013 Aug, Vol 2, Issue 8. Link to Abstract